PvE should should be just that, PvE. Mixing PvE and PvP is just asking for ganking and griefing. Thats one of the most certain paths to a narrow niche market(and limited profit).
Not that I'm against the fact that the company needs money to survive, I realize there are responsibilities and I would certainly want the people who make this game possible to get a great pay day, but it's not just about money. the moment you start making a game for profit alone, it's simply dead. What you're asking for in this paragraph is essentially your standard mmo, with no consequences, no REAL skill, and no intelligence required.
It doesn't matter how advanced "AI" will get, because it's still a program, and it's never truly random. The only thing that can make PVE truly challenging is the randomness that comes from other players possibly helping/ruining/stealing/killing/changing the field of play.
Also, there is no way PVE can be without the dangers of PVP because you're then truly guaranteeing that the market will primarily come from that and that alone. All the mods/mins/nic you could ask for just by running missions with complete 100% safety? That's truly game-breaking, especially with the free market setup.
Just like this game isn't EVE, it isn't WoW either, and it shouldn't be. Why not create something unique that balances the best of both worlds, and make something truly different, but that works and actually makes people WANT to play it? It can be done, but not by copying already done stuff that doesn't work like that.