Well the best way for me is to minimize relocking tiles and reactivate miners. So with a Riveler mk2 would be to set 5 tiles with each laser as far away as possible, with a small red sized (sitting bot at the centre) patch can be set for around 2hrs or so without changing tiles.
Seen others just setting it all lasers on 1 tile. This was popular in the good old days of liquid epitron mining, but it was changed to an ore as it is now. I dont know why the placed all on one tile though
I guess effeciency starts by learning not to use a geoscanner on miner and fit another tuner, scan area first with argano. Also, how accurate is your scanning btw? . If its not 100% you can really judge the liquid flow behaviour.
RIP PERPETUUM